Call for Abstracts of Poster Presentation
We would like to announce that excellent lectures and poster presentations related to oral sciences: biomaterials and tissue engineering, oral physiological problems, oral health improvement, and dental nursing and educational system will be presented in the 4th ASEAN plus and TOKUSHIMA Joint International Conference on “Challenging and Innovation in Oral Sciences”.
This meeting will be taken place in Bali, Indonesia on Dec 1-3, 2017. We would be pleased if you recommend a faculty member and a graduate student in your university as participants and poster presenters. Researchers from Indonesia, Japan, and other Asian countries and world will attend the conference and all the participants will have an excellent opportunity to discuss their current knowledge on oral sciences.
We expect 120 delegates to attend the meeting with 25 scientific abstracts of
poster presentation. Yours sincerely,
Fumiaki Kawano, Co-Presidents
Dean, Faculty of Dentistry
Tokushima University, Tokushima, Japan
Suryono SH, Co-Presidents
Dean, Faculty of Dentistry
Universitas Islam Sultan Agung, Semarang, Indonesia
Contents of Abstracts
The word limit for abstract is 400 words. Title, authors, and authors’ affiliation are not included in the 400 word limit. The abstract must contain the following elements: objective, methods, results – data and statistical analysis, and conclusion.
Competition is planned. All poster presenters are invited to enter the poster competition. The winners will be notified at the conference on Saturday at 10:00 a.m. In judging, the Awards Review Committee will consider the following participation:
1. Originality and design of the investigation
2. Quality of the data produced
3. Suitability of the methods of analysis used
4. Scientific value of the work
5. Quality of the poster presentation
Please prepare the abstract with Microsoft Word with the following layout. Please send your abstract via web-site.
Deadline for the submission is October 15, 2017.
TITLE OF POSTER PRESENTATION:
Presenter’s name with underline and co-author(s) name Department, University/Institute, Address including city and country
e-mail address for correspondence
Objectives: Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly affects several joints of the body. Increased subchondral trabecular bone turnover due to imbalanced bone-resorbing and bone-forming activities is a hallmark of RA. It has been previously postulated that aberrant apoptosis or migration of cells from the subchondral bone may be responsible for the pathogenesis of RA. The temporomandibular joint (TMJ) is frequently affected in human RA. However, the involvement of TMJ in RA remains unclear. The aim of this study was to investigate the effects of the Fas and Sphingosine-1-phosphatase (S1P) signaling pathways on osteoclast precursors that participate in the pathogenesis of RA in the TMJ.
Materials and Methods: TMJs were resected from 8-22-week-old female MRL/lpr (n=20) and MRL+/(n=15) mice. Micro-computed tomography (CT), histological, and immunohistochemical analyses were performed to assess subchondral bone resorption. Bone marrow macrophages (BMMs) from MRL/lpr and MRL+/femur were harvested for tartrate-resistant acid phosphatase (TRAP) stain and western blot analysis. RNA isolation from cartilage/subchondral bone interface of the TMJ was carried out to examine the expression of osteoclastogenic and S1P/S1P-receptor marker genes. Results: Micro-CT and TRAP stain revealed more severe subchondral bone resorption in MRL/lpr than in MRL+/mice, with a greater number of osteoclasts in the subchondral bone. On the other hand, lower levels of collagen type II, aggrecan, and osteoprotegerin and higher levels of MMP9, MMP13, VEGF and S1P-receptor-1 (S1P1) were detected in the MRL/lpr mandibular condyles. The western blot analysis showed higher protein expression levels of osteoclastogenic markers (e.g NFATc1, c-Fos, and c-Src) in MRL/lpr than in MRL+/ . Furthermore, expression of Sphk1 and S1P1 were significantly higher in the MRL/lpr mandibular condyles. Conclusion: It is concluded that the Fas/S1P1 signaling pathway in osteoclast precursors plays an important role in the pathogenesis of RA in TMJ.Leave a reply