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4th Asean plus and Tokushima Joint International Conference

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Call for Abstracts of Poster Presentation

We  would  like  to  announce that  excellent  lectures  and  poster presentations related to oral sciences: biomaterials and  tissue engineering, oral physiological problems, oral health improvement, and  dental nursing and  educational system will be  presented in the  4th  ASEAN plus and  TOKUSHIMA Joint International Conference on “Challenging and Innovation in Oral Sciences”.

This meeting will be taken  place in Bali, Indonesia on Dec 1-3, 2017.  We would be pleased if you recommend a faculty member and  a graduate student in your university as participants and  poster presenters. Researchers from Indonesia, Japan, and  other  Asian  countries  and  world  will attend the  conference  and  all the   participants  will  have   an   excellent  opportunity  to  discuss  their  current knowledge on oral sciences.

We  expect 120  delegates  to attend the  meeting  with  25  scientific  abstracts of

poster presentation. Yours sincerely,

Fumiaki Kawano, Co-Presidents

Dean, Faculty of Dentistry

Tokushima University, Tokushima, Japan


Suryono SH, Co-Presidents

Dean, Faculty of Dentistry

Universitas Islam Sultan Agung, Semarang, Indonesia

Contents of Abstracts

The  word limit for abstract is 400  words. Title, authors, and  authors’ affiliation are  not  included in the  400  word  limit. The  abstract must contain  the  following  elements:  objective,  methods, results  - data and statistical analysis, and conclusion.


Competition is planned. All poster presenters are  invited to enter  the poster competition. The winners will be notified at the conference on Saturday at  10:00  a.m.  In judging,  the  Awards Review  Committee will consider the following participation:

1. Originality and design of the investigation

2. Quality of the data  produced

3. Suitability of the methods of analysis used

4. Scientific value of the work

5. Quality of the poster presentation

Submission process

Please  prepare the  abstract with  Microsoft  Word  with  the  following layout. Please send your abstract via web-site.

Deadline for the submission is October 15, 2017.


Presenter’s name with underline and co-author(s) name Department,   University/Institute,   Address   including   city   and country

e-mail address for correspondence


Objectives: Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly affects several joints of the body. Increased subchondral trabecular bone  turnover  due to imbalanced bone-resorbing and  bone-forming activities is a hallmark of RA. It has been previously postulated that aberrant apoptosis or migration of cells from the subchondral bone  may  be  responsible for the  pathogenesis of RA. The  temporomandibular joint (TMJ) is frequently affected in human RA. However, the  involvement of TMJ in RA remains unclear. The  aim of this study was to investigate the  effects of the  Fas and Sphingosine-1-phosphatase (S1P)   signaling pathways on  osteoclast precursors that participate in the pathogenesis of RA in the TMJ.

Materials  and   Methods:  TMJs  were   resected  from  8-22-week-old  female  MRL/lpr (n=20)  and MRL+/(n=15)  mice.  Micro-computed  tomography (CT),  histological,  and immunohistochemical    analyses    were    performed    to    assess subchondral    bone resorption.   Bone   marrow   macrophages  (BMMs)   from   MRL/lpr   and   MRL+/femur were harvested for tartrate-resistant acid phosphatase (TRAP) stain and  western blot analysis.  RNA  isolation  from  cartilage/subchondral  bone   interface  of  the  TMJ  was carried  out  to  examine  the   expression  of  osteoclastogenic  and   S1P/S1P-receptor marker  genes. Results: Micro-CT and  TRAP stain revealed more  severe subchondral bone  resorption in MRL/lpr than  in MRL+/mice, with a greater number of osteoclasts in the subchondral bone.   On   the    other    hand,   lower   levels   of   collagen   type    II,   aggrecan,  and osteoprotegerin and  higher levels of MMP9, MMP13, VEGF and  S1P-receptor-1 (S1P1) were   detected  in  the   MRL/lpr  mandibular  condyles.  The   western  blot  analysis showed higher  protein  expression  levels  of  osteoclastogenic  markers  (e.g  NFATc1, c-Fos, and  c-Src)  in  MRL/lpr  than  in  MRL+/ . Furthermore, expression  of Sphk1  and S1P1  were significantly higher in the MRL/lpr mandibular condyles. Conclusion:  It   is  concluded  that   the   Fas/S1P1     signaling  pathway  in  osteoclast precursors plays an important role in the pathogenesis of RA in TMJ.